NovaMeds
Evidence-based guides to medicines, active ingredients and emerging research.
TB-500 is a synthetic peptide based on the active domain of Thymosin Beta-4. We examine how actin sequestration regulates cell migration, preclinical tissue repair data, anti-doping bans and research status.
GHK-Cu is a naturally occurring copper-binding tripeptide that regulates extracellular matrix remodelling and gene expression. We review the evidence behind its collagen-stimulating, wound-healing and dermatological properties.
Tretinoin is pure all-trans retinoic acid; retinol must undergo a two-step intracellular conversion. We compare their molecular pharmacology, clinical anti-ageing efficacy, irritation management and prescribing status.
Isotretinoin remains the only disease-modifying, curative therapy for severe recalcitrant acne. We examine how it shrinks sebaceous glands by 90%, cumulative dose maths, monitoring protocols and safety.
Modafinil is a wakefulness-promoting eugeroic distinct from traditional amphetamines. We examine how low-affinity dopamine transport and orexin signaling promote wakefulness, cognitive trial data and drug interactions.
Lisdexamfetamine is a molecular prodrug requiring enzymatic cleavage in red blood cells to yield active d-amphetamine. We examine its 12-hour smooth plasma curve, ADHD and binge-eating efficacy and reduced abuse liability.
Testosterone undecanoate is available as a long-acting 10–14 week intramuscular depot and as a novel oral formulation absorbed via the lymphatic system. We review the pharmacology, TRAVERSE safety data and monitoring.
Discontinuing GLP-1 receptor agonists leads to substantial weight regain in clinical trials. Here is what the STEP-1 extension and SURMOUNT-4 studies reveal about metabolic adaptation, appetite recovery and long-term weight management.
Ozempic and Wegovy both contain semaglutide. Learn how their authorized uses, doses and formulations differ in the UK and US, and what the evidence shows.
Mounjaro and Zepbound both contain tirzepatide. Learn why they carry different names and indications in the US, and why only Mounjaro is authorized in the UK.
Wegovy (semaglutide) and Saxenda (liraglutide) compared: dosing, authorized uses in the UK and US, and the STEP 8 head-to-head trial.
Semaglutide can be taken as a daily tablet or a weekly injection. Learn how absorption, doses, rules for taking it and authorized uses differ in the UK and US.