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Longevity
Rapamycin
Sirolimus · Sirolimus
Sirolimus, an mTOR inhibitor authorised as an immunosuppressant after kidney transplantation.
- Partner pharmacy
- Personal assistance
- Discreet delivery
- Active ingredientSirolimus
- AdministrationOral
Shipping & Delivery
- Normally dispatched within 24 hours of payment confirmation.
- UPS Express · £12 · Approx. 7–9 business days
- Registered Mail · £8 · Approx. 14–20 business days
What Rapamycin is
Rapamycin (sirolimus) is an inhibitor of mTOR, a key regulator of cell growth. It is authorised as an immunosuppressant to prevent organ rejection after kidney transplantation. Its role in ageing is an area of research; there is no authorised indication for longevity.
Suitability and dosing are decided by a prescriber on the basis of the approved product information.
mTOR inhibition: authorised uses and research
Sirolimus inhibits mTOR, a protein that regulates cell growth and proliferation. In the immune system this blocks the proliferation of T cells, which is why it is used to prevent rejection after kidney transplantation.
AuthorisedPrevention of kidney transplant rejection, as set out in the product information.
ResearchLifespan effects in animal studies; no proven benefit for human ageing.
Interest in ageing comes largely from animal studies, such as the extension of lifespan in mice.1 These findings have not been shown to apply to people.
Side effects and warnings
As an immunosuppressant, it has significant side effects:
- Increased risk of infections
- Mouth ulcers, raised cholesterol and triglycerides
- Anaemia and other changes in blood counts
- Delayed wound healing
ImportantUse outside authorised indications is not supported by clinical evidence in humans. Blood levels, lipids and blood counts are monitored, and many medicines and grapefruit juice affect its levels. Always read the patient information leaflet.
Product information
Common questions
Do I need a prescription?
Rapamycin is a prescription-only medicine. After your request, the partner pharmacy verifies whether and how supply is possible, for example through an existing prescription or an assessment by an independent doctor where permitted.
Is it authorised for longevity?
No. Sirolimus is authorised as an immunosuppressant. Its role in ageing is an area of research, and there is no authorised indication for longevity.
Do I pay when I send a request?
No. Payment is arranged individually with customer service once your request has been reviewed and can proceed.
Sources
- Harrison DE, et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature. 2009;460:392–395.
- Rapamune: Summary of Product Characteristics. Pfizer.
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