{"id":61,"date":"2026-09-29T15:20:39","date_gmt":"2026-09-29T19:20:39","guid":{"rendered":"https:\/\/novameds.health\/us\/product\/rapamycin\/"},"modified":"2026-10-01T09:02:11","modified_gmt":"2026-10-01T13:02:11","slug":"rapamycin","status":"publish","type":"product","link":"https:\/\/novameds.health\/us\/product\/rapamycin\/","title":{"rendered":"Rapamycin"},"content":{"rendered":"\n<section id=\"overview\" data-nav=\"Overview\"><span class=\"kicker\">Overview<\/span><h2>What Rapamycin is<\/h2><p>Rapamycin (sirolimus) is an inhibitor of mTOR, a key regulator of cell growth. It is authorized as an immunosuppressant to prevent organ rejection after kidney transplantation. Its role in aging is an area of research; there is no authorized indication for longevity.<\/p><p>Suitability and dosing are decided by a prescriber on the basis of the approved product information.<\/p><\/section>\n<section id=\"how\" data-nav=\"How it works\"><span class=\"kicker\">How it works<\/span><h2>mTOR inhibition: <em>authorized uses and research<\/em><\/h2><p>Sirolimus inhibits mTOR, a protein that regulates cell growth and proliferation. In the immune system this blocks the proliferation of T cells, which is why it is used to prevent rejection after kidney transplantation.<\/p><div class=\"mech\"><div><b>Authorized<\/b><span>Prevention of kidney transplant rejection, as set out in the product information.<\/span><\/div><div><b>Research<\/b><span>Lifespan effects in animal studies; no proven benefit for human aging.<\/span><\/div><\/div><p>Interest in aging comes largely from animal studies, such as the extension of lifespan in mice.<sup><a href=\"#references\">1<\/a><\/sup> These findings have not been shown to apply to people.<\/p><\/section>\n<section id=\"safety\" data-nav=\"Safety\"><span class=\"kicker\">Safety<\/span><h2>Side effects and warnings<\/h2><p>As an immunosuppressant, it has significant side effects:<\/p><ul class=\"bul\"><li>Increased risk of infections<\/li><li>Mouth ulcers, raised cholesterol and triglycerides<\/li><li>Anemia and other changes in blood counts<\/li><li>Delayed wound healing<\/li><\/ul><div class=\"warn\"><svg class=\"icon\" aria-hidden=\"true\"><use href=\"#i-alert\"\/><\/svg><div><strong>Important<\/strong>Use outside authorized indications is not supported by clinical evidence in humans. Blood levels, lipids and blood counts are monitored, and many medicines and grapefruit juice affect its levels. Always read the patient information leaflet.<\/div><\/div><\/section>\n<section id=\"documents\" data-nav=\"Documents\"><span class=\"kicker\">Documents<\/span><h2>Product information<\/h2><div class=\"docs\"><a class=\"doc-row\" href=\"https:\/\/labeling.pfizer.com\/ShowLabeling.aspx?format=PDF&#038;id=139\" target=\"_blank\" rel=\"noopener\"><span class=\"ico\"><svg class=\"icon\" aria-hidden=\"true\"><use href=\"#i-file\"\/><\/svg><\/span><span>Patient information leaflet<small>Patient information, in the Prescribing Information PDF<\/small><\/span><span class=\"end\">PDF<span class=\"visually-hidden\"> (opens in a new tab)<\/span><\/span><\/a><a class=\"doc-row\" href=\"https:\/\/labeling.pfizer.com\/ShowLabeling.aspx?format=PDF&#038;id=139\" target=\"_blank\" rel=\"noopener\"><span class=\"ico\"><svg class=\"icon\" aria-hidden=\"true\"><use href=\"#i-file\"\/><\/svg><\/span><span>Prescribing Information<small>Rapamune \u00b7 official document<\/small><\/span><span class=\"end\">PDF<span class=\"visually-hidden\"> (opens in a new tab)<\/span><\/span><\/a><\/div><\/section>\n<section id=\"faq\" data-nav=\"FAQ\"><span class=\"kicker\">FAQ<\/span><h2>Common questions<\/h2><div class=\"faq\" style=\"margin-top:18px\"><details open><summary>Do I need a prescription?<svg class=\"icon\" aria-hidden=\"true\"><use href=\"#i-plus\"\/><\/svg><\/summary><p>Rapamycin is a prescription-only medicine. After your request, the partner pharmacy verifies whether and how supply is possible, for example through an existing prescription or an assessment by an independent doctor where permitted.<\/p><\/details><details><summary>Is it authorized for longevity?<svg class=\"icon\" aria-hidden=\"true\"><use href=\"#i-plus\"\/><\/svg><\/summary><p>No. Sirolimus is authorized as an immunosuppressant. Its role in aging is an area of research, and there is no authorized indication for longevity.<\/p><\/details><details><summary>Do I pay when I send a request?<svg class=\"icon\" aria-hidden=\"true\"><use href=\"#i-plus\"\/><\/svg><\/summary><p>No. Payment is arranged individually with customer service once your request has been reviewed and can proceed.<\/p><\/details><\/div><\/section>\n<section id=\"references\" data-nav=\"References\"><span class=\"kicker\">References<\/span><h2>Sources<\/h2><ol class=\"refs\"><li><span>Harrison DE, et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. <i>Nature<\/i>. 2009;460:392\u2013395.<\/span><\/li><li><span>Rapamune: Prescribing Information. Pfizer.<\/span><\/li><\/ol><\/section>\n","protected":false},"excerpt":{"rendered":"<p>Sirolimus, an mTOR inhibitor authorized as an immunosuppressant after kidney transplantation.<\/p>\n","protected":false},"featured_media":216,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[20],"product_tag":[25],"nm_classification":[],"class_list":["post-61","product","type-product","status-publish","has-post-thumbnail","product_cat-longevity-cellular-health","product_tag-prescription","first","instock","shipping-taxable","purchasable","product-type-variable"],"_links":{"self":[{"href":"https:\/\/novameds.health\/us\/wp-json\/wp\/v2\/product\/61","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/novameds.health\/us\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/novameds.health\/us\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/novameds.health\/us\/wp-json\/wp\/v2\/comments?post=61"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/novameds.health\/us\/wp-json\/wp\/v2\/media\/216"}],"wp:attachment":[{"href":"https:\/\/novameds.health\/us\/wp-json\/wp\/v2\/media?parent=61"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/novameds.health\/us\/wp-json\/wp\/v2\/product_brand?post=61"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/novameds.health\/us\/wp-json\/wp\/v2\/product_cat?post=61"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/novameds.health\/us\/wp-json\/wp\/v2\/product_tag?post=61"},{"taxonomy":"nm_classification","embeddable":true,"href":"https:\/\/novameds.health\/us\/wp-json\/wp\/v2\/nm_classification?post=61"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}