{"id":52,"date":"2026-09-29T15:20:39","date_gmt":"2026-09-29T19:20:39","guid":{"rendered":"https:\/\/novameds.health\/us\/product\/mysimba\/"},"modified":"2026-10-01T09:02:11","modified_gmt":"2026-10-01T13:02:11","slug":"mysimba","status":"publish","type":"product","link":"https:\/\/novameds.health\/us\/product\/mysimba\/","title":{"rendered":"Mysimba"},"content":{"rendered":"\n
Overview<\/span>

What Mysimba is<\/h2>

Mysimba combines naltrexone, an opioid antagonist, and bupropion, a noradrenaline and dopamine reuptake inhibitor, in prolonged-release tablets. It is used, alongside diet and physical activity, for weight management in adults. In the US the same combination is marketed as Contrave.<\/p>

Suitability and dosing are decided by a prescriber on the basis of the approved product information.<\/p><\/section>\n

How it works<\/span>

Two medicines, one prolonged-release tablet<\/em><\/h2>

Naltrexone and bupropion act on areas of the brain involved in appetite and in the reward associated with food. The exact way the combination reduces food intake is not fully understood.<\/p>

Bupropion<\/b>Inhibits the reuptake of dopamine and noradrenaline.<\/span><\/div>
Naltrexone<\/b>Opioid receptor antagonist.<\/span><\/div><\/div>

In the COR-I trial, adults with obesity or overweight lost more weight over 56 weeks with naltrexone\u2013bupropion than with placebo, alongside diet and exercise.1<\/a><\/sup><\/p><\/section>\n

Safety<\/span>

Side effects and warnings<\/h2>

Commonly reported side effects include:<\/p>

  • Nausea, constipation, vomiting and dry mouth<\/li>
  • Headache, dizziness and difficulty sleeping<\/li>
  • Increases in blood pressure and heart rate<\/li>
  • A risk of seizures, which rules out use in people with seizure disorders<\/li><\/ul>
    <\/svg>
    Important<\/strong>Must not be used by people with a seizure disorder, uncontrolled high blood pressure, or who are taking opioid medicines. Contact a doctor promptly about mood changes or suicidal thoughts. Always read the patient information leaflet.<\/div><\/div><\/section>\n
    Documents<\/span>

    Product information<\/h2>
    <\/svg><\/span>Patient information leafletSupplied by the partner pharmacy<\/small><\/span><\/div>
    <\/svg><\/span>Prescribing InformationOfficial product information<\/small><\/span><\/div><\/div><\/section>\n
    FAQ<\/span>

    Common questions<\/h2>
    Do I need a prescription?<\/svg><\/summary>

    Mysimba is a prescription-only medicine. After your request, the partner pharmacy verifies whether and how supply is possible, for example through an existing prescription or an assessment by an independent doctor where permitted.<\/p><\/details>

    Is it the same as Contrave?<\/svg><\/summary>

    Yes. The same combination of naltrexone and bupropion is marketed as Contrave in the US and as Mysimba in the UK and the EU.<\/p><\/details>

    How soon is its effect reviewed?<\/svg><\/summary>

    The product information sets a review point: treatment should be stopped after 16 weeks if at least 5% of initial body weight has not been lost.<\/p><\/details>

    Do I pay when I send a request?<\/svg><\/summary>

    No. Payment is arranged individually with customer service once your request has been reviewed and can proceed.<\/p><\/details><\/div><\/section>\n

    References<\/span>

    Sources<\/h2>
    1. Greenway FL, et al. Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): a multicentre, randomized, double-blind, placebo-controlled, phase 3 trial. Lancet<\/i>. 2010;376:595\u2013605.<\/span><\/li>
    2. Mysimba: Prescribing Information.<\/span><\/li><\/ol><\/section>\n","protected":false},"excerpt":{"rendered":"

      A fixed combination of naltrexone and bupropion used for weight management.<\/p>\n","protected":false},"featured_media":191,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[16],"product_tag":[25],"nm_classification":[],"class_list":["post-52","product","type-product","status-publish","has-post-thumbnail","product_cat-weight-management-metabolism","product_tag-prescription","first","instock","shipping-taxable","purchasable","product-type-variable"],"_links":{"self":[{"href":"https:\/\/novameds.health\/us\/wp-json\/wp\/v2\/product\/52","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/novameds.health\/us\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/novameds.health\/us\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/novameds.health\/us\/wp-json\/wp\/v2\/comments?post=52"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/novameds.health\/us\/wp-json\/wp\/v2\/media\/191"}],"wp:attachment":[{"href":"https:\/\/novameds.health\/us\/wp-json\/wp\/v2\/media?parent=52"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/novameds.health\/us\/wp-json\/wp\/v2\/product_brand?post=52"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/novameds.health\/us\/wp-json\/wp\/v2\/product_cat?post=52"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/novameds.health\/us\/wp-json\/wp\/v2\/product_tag?post=52"},{"taxonomy":"nm_classification","embeddable":true,"href":"https:\/\/novameds.health\/us\/wp-json\/wp\/v2\/nm_classification?post=52"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}