{"id":158,"date":"2026-09-30T19:46:27","date_gmt":"2026-09-30T23:46:27","guid":{"rendered":"https:\/\/novameds.health\/ca\/product\/ngenla\/"},"modified":"2026-10-01T11:31:36","modified_gmt":"2026-10-01T15:31:36","slug":"ngenla","status":"publish","type":"product","link":"https:\/\/novameds.health\/ca\/product\/ngenla\/","title":{"rendered":"Ngenla"},"content":{"rendered":"\n<section id=\"overview\" data-nav=\"Overview\"><span class=\"kicker\">Overview<\/span><h2>What Ngenla is<\/h2><p>Ngenla contains somatrogon, a long-acting recombinant human growth hormone. It is given as a once-weekly injection for the treatment of children and adolescents with growth disturbance due to growth hormone deficiency.<\/p><p>Suitability and dosing are decided by a prescriber on the basis of the approved product information.<\/p><\/section>\n<section id=\"how\" data-nav=\"How it works\"><span class=\"kicker\">How it works<\/span><h2>Growth hormone, <em>once a week<\/em><\/h2><p>Somatrogon is recombinant human growth hormone joined to short peptide sequences taken from human chorionic gonadotropin. These extend its half-life, which allows one injection a week instead of daily injections.<\/p><div class=\"mech\"><div><b>Growth hormone receptor<\/b><span>Stimulates growth and IGF-1 production.<\/span><\/div><div><b>Extended half-life<\/b><span>Once-weekly injection.<\/span><\/div><\/div><p>In the pivotal phase 3 trial in children with growth hormone deficiency, weekly somatrogon was non-inferior to daily somatropin for height velocity at 12 months.<sup><a href=\"#references\">1<\/a><\/sup><\/p><\/section>\n<section id=\"safety\" data-nav=\"Safety\"><span class=\"kicker\">Safety<\/span><h2>Side effects and warnings<\/h2><p>Commonly reported side effects include:<\/p><ul class=\"bul\"><li>Injection-site reactions<\/li><li>Headache and fever<\/li><li>Changes in thyroid function, which are monitored<\/li><\/ul><div class=\"warn\"><svg class=\"icon\" aria-hidden=\"true\"><use href=\"#i-alert\"\/><\/svg><div><strong>Important<\/strong>Must not be used once the growth plates have closed or with active cancer. Treatment is started and monitored by a specialist. Always read the patient information leaflet.<\/div><\/div><\/section>\n<section id=\"documents\" data-nav=\"Documents\"><span class=\"kicker\">Documents<\/span><h2>Product information<\/h2><div class=\"docs\"><a class=\"doc-row\" href=\"https:\/\/www.medicines.org.uk\/emc\/product\/13486\/pil\" target=\"_blank\" rel=\"noopener\"><span class=\"ico\"><svg class=\"icon\" aria-hidden=\"true\"><use href=\"#i-file\"\/><\/svg><\/span><span>Patient information leaflet<small>Ngenla pre-filled pen \u00b7 electronic medicines compendium<\/small><\/span><span class=\"end\">emc<span class=\"visually-hidden\"> (opens in a new tab)<\/span><\/span><\/a><a class=\"doc-row\" href=\"https:\/\/www.medicines.org.uk\/emc\/product\/13486\/smpc\" target=\"_blank\" rel=\"noopener\"><span class=\"ico\"><svg class=\"icon\" aria-hidden=\"true\"><use href=\"#i-file\"\/><\/svg><\/span><span>Summary of Product Characteristics<small>Ngenla pre-filled pen \u00b7 electronic medicines compendium<\/small><\/span><span class=\"end\">emc<span class=\"visually-hidden\"> (opens in a new tab)<\/span><\/span><\/a><\/div><\/section>\n<section id=\"faq\" data-nav=\"FAQ\"><span class=\"kicker\">FAQ<\/span><h2>Common questions<\/h2><div class=\"faq\" style=\"margin-top:18px\"><details open><summary>Do I need a prescription?<svg class=\"icon\" aria-hidden=\"true\"><use href=\"#i-plus\"\/><\/svg><\/summary><p>Ngenla is a prescription-only medicine. After your request, the partner pharmacy verifies whether and how supply is possible, for example through an existing prescription or an assessment by an independent doctor where permitted.<\/p><\/details><details><summary>Who is it for?<svg class=\"icon\" aria-hidden=\"true\"><use href=\"#i-plus\"\/><\/svg><\/summary><p>Children and adolescents with growth disturbance due to insufficient growth hormone, as set out in the product information. Treatment is started by a specialist.<\/p><\/details><details><summary>How is it different from daily growth hormone?<svg class=\"icon\" aria-hidden=\"true\"><use href=\"#i-plus\"\/><\/svg><\/summary><p>The growth hormone effect is the same; the longer half-life allows one injection a week instead of one a day.<\/p><\/details><details><summary>Do I pay when I send a request?<svg class=\"icon\" aria-hidden=\"true\"><use href=\"#i-plus\"\/><\/svg><\/summary><p>No. Payment is arranged individually with customer service once your request has been reviewed and can proceed.<\/p><\/details><\/div><\/section>\n<section id=\"references\" data-nav=\"References\"><span class=\"kicker\">References<\/span><h2>Sources<\/h2><ol class=\"refs\"><li><span>Deal CL, et al. Somatrogon growth hormone in the treatment of pediatric growth hormone deficiency: results of the pivotal pediatric phase 3 clinical trial. <i>J Clin Endocrinol Metab<\/i>. 2022;107:e2717\u2013e2728.<\/span><\/li><li><span>Ngenla: Summary of Product Characteristics. Pfizer.<\/span><\/li><\/ol><\/section>\n","protected":false},"excerpt":{"rendered":"<p>A long-acting growth hormone given once weekly for growth hormone deficiency in children.<\/p>\n","protected":false},"featured_media":217,"comment_status":"open","ping_status":"closed","template":"","meta":[],"product_brand":[],"product_cat":[25],"product_tag":[41],"nm_classification":[],"class_list":["post-158","product","type-product","status-publish","has-post-thumbnail","product_cat-hormonal-health-growth","product_tag-prescription","first","instock","shipping-taxable","purchasable","product-type-variable"],"_links":{"self":[{"href":"https:\/\/novameds.health\/ca\/wp-json\/wp\/v2\/product\/158","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/novameds.health\/ca\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/novameds.health\/ca\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/novameds.health\/ca\/wp-json\/wp\/v2\/comments?post=158"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/novameds.health\/ca\/wp-json\/wp\/v2\/media\/217"}],"wp:attachment":[{"href":"https:\/\/novameds.health\/ca\/wp-json\/wp\/v2\/media?parent=158"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/novameds.health\/ca\/wp-json\/wp\/v2\/product_brand?post=158"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/novameds.health\/ca\/wp-json\/wp\/v2\/product_cat?post=158"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/novameds.health\/ca\/wp-json\/wp\/v2\/product_tag?post=158"},{"taxonomy":"nm_classification","embeddable":true,"href":"https:\/\/novameds.health\/ca\/wp-json\/wp\/v2\/nm_classification?post=158"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}